For people 6+ with moderate to severe plaque psoriasis

Results fast. Clear skin that can last.

In clinical trials, 6 out of 10 people taking COSENTYX 300 mg were clear or almost clear at 12 weeks vs ~5% taking placebo. Approximately 8 out of 10 people saw 75% skin clearance compared to those not taking COSENTYX. Approximately 6 out of 10 people saw 90% skin clearance compared to those not taking COSENTYX.

Many who saw results at 1 year maintained them at 5 years.^†

^†After 3 years, patients and doctors were told which medication was being used. Knowing the study drug being used may affect the results.

90% skin clearance at 12 weeks, 1 year, and 5 years

Among those moderate to severe plaque psoriasis patients who kept a symptom diary (39% of people), people taking COSENTYX reported an improvement in symptoms like pain, itching, and scaling at 12 weeks, compared with those not taking COSENTYX (placebo) in the studies.

See before and after pictures of how well COSENTYX works on troublesome areas, like the scalp, nails, palms, and bottoms of feet.

.

Plaque psoriasis treatment on scalp before and after COSENTYX — **Scalp**

Plaque psoriasis treatment on nails before and after COSENTYX — **Nails**

Plaque psoriasis treatment on palms before and after COSENTYX — Palms

Plaque psoriasis treatment on bottom of feet before and after COSENTYX — Bottoms of feet

^§At week 12, 53% of people on COSENTYX 300 mg saw 90% scalp clearance compared with 2% taking placebo.
^||Nail psoriasis improved by more than 46% in people receiving COSENTYX 300 mg compared to an improvement of about 12% in people receiving placebo at week 16.
^¶Over 30% of people on COSENTYX 300 mg were clear or almost clear on their palms and the bottoms of their feet at 16 weeks compared to 1.5% with placebo.

Real people are seeing and feeling real results, especially on troublesome areas:

LauraLee actual patient — Individual results may vary. LauraLee was compensated for her time.

“My scalp was terrible. I just let my mom trim my hair. I didn’t want to go in and have someone wash my hair and see my scalp."

"Now that I’m clear, I’m not as restricted. I can get it professionally cut.”

Dewey actual patient — Individual results may vary. Dewey was compensated for his time.

“I had it all the way up to the fingertips, including the nails. At the cashout line, the cashier would ask me to pay with a card so she wouldn’t have to touch my money. That was everyday life.”

"Now it’s the best feeling to be in public. I’m clear.”

What’s the connection between plaque psoriasis and psoriatic arthritis?

Many people with plaque psoriasis may develop psoriatic arthritis, especially if they have plaques on their nails and scalp. If left untreated, psoriatic arthritis can cause permanent joint damage. COSENTYX works to treat all of this, and helps stop further joint damage. Talk to your doctor if you recognize these symptoms to learn more.

In another trial, up to 60% of patients taking COSENTYX 150 mg saw at least a 20% improvement in psoriatic arthritis symptoms at 16 weeks versus 18% of patients taking placebo.

BETTER TOGETHER

See how Cyndi, Brenelle, Darren, Dewey, Gary, Jordan, LauraLee, and Nadia are doing years into taking COSENTYX, as they get together to celebrate something special.

And to get to know our patient advocates even better, WATCH the entire BETTER TOGETHER series and other COSENTYX stories on our patient videos page.

Tap to see IMPORTANT SAFETY INFORMATION AND APPROVED USES

IMPORTANT SAFETY INFORMATION

Do not use COSENTYX if you have had a severe allergic reaction to secukinumab or any of the other ingredients in COSENTYX. See the Medication Guide for a complete list of ingredients.

What is the most important information I should know about COSENTYX?

COSENTYX is a medicine that affects your immune system. COSENTYX may increase your risk of having serious side effects such as…

Do not use COSENTYX if you have had a severe allergic reaction to secukinumab or any of the other ingredients in COSENTYX. See the Medication Guide for a complete list of ingredients.

What is the most important information I should know about COSENTYX?

COSENTYX is a medicine that affects your immune system. COSENTYX may increase your risk of having serious side effects such as:

Infections

COSENTYX may lower the ability of your immune system to fight infections and may increase your risk of infections. Some people have died from these infections.

Your doctor should check you for tuberculosis (TB) before starting treatment with COSENTYX.
If your doctor feels that you are at risk for TB, you may be treated with medicine for TB before you begin treatment with COSENTYX and during treatment with COSENTYX.
Your doctor should watch you closely for signs and symptoms of TB during treatment with COSENTYX. Do not use COSENTYX if you have an active TB infection.

Before starting COSENTYX, tell your doctor if you:

are being treated for an infection
have an infection that does not go away or that keeps coming back
have TB or have been in close contact with someone with TB
think you have an infection or have symptoms of an infection such as: fevers, sweats, or chills; muscle aches; cough; shortness of breath; blood in your phlegm; weight loss; warm, red, or painful skin or sores on your body; diarrhea or stomach pain; burning when you urinate or urinate more often than normal

After starting COSENTYX, call your doctor right away if you have any signs of infection listed above. Do not use COSENTYX if you have any signs of infection unless you are instructed to by your doctor.

What are the possible side effects of COSENTYX?

COSENTYX may cause serious side effects, including:

Serious allergic reactions

Serious allergic reactions can occur. Get emergency medical help right away if you get any of the following symptoms: feeling faint; swelling of your face, eyelids, lips, mouth, tongue, or throat; trouble breathing or throat tightness; chest tightness; skin rash or hives (red, itchy bumps).

If you have a severe allergic reaction, do not give another injection of COSENTYX.

Inflammatory bowel disease

New cases of inflammatory bowel disease or "flare-ups" can happen with COSENTYX, and can sometimes be serious. If you have inflammatory bowel disease (ulcerative colitis or Crohn's disease), tell your doctor if you have worsening disease symptoms during treatment with COSENTYX or develop new symptoms of stomach pain or diarrhea.

Severe skin reactions that look like eczema can happen during treatment with COSENTYX from days to months after your first dose and can sometimes lead to hospitalization. Your doctor may temporarily stop treatment with COSENTYX if you develop severe skin reactions. Tell your doctor if you have any of the following signs or symptoms: redness or rash; itching; small bumps or patches; your skin is dry or feels like leather; blisters on the hands or feet that ooze or become crusty or skin peeling.

The most common side effects of COSENTYX include: cold symptoms, diarrhea, and upper respiratory tract infections.

These are not all of the possible side effects of COSENTYX. Call your doctor for medical advice about side effects.

Before using COSENTYX, tell your doctor if you:

have any of the conditions or symptoms listed above for infections.
have inflammatory bowel disease (Crohn's disease or ulcerative colitis).
are allergic to latex. The needle cap on the COSENTYX Sensoready® pen, and 150 mg/mL and 75 mg/0.5 mL prefilled syringes contains latex.
have recently received or are scheduled to receive an immunization (vaccine). People who take COSENTYX should not receive live vaccines. Children should be brought up to date with all vaccines before starting COSENTYX.
have any other medical conditions and all the medicines you take, including prescription and over‑the‑counter medicines, vitamins, and herbal supplements. Keep a list of your medicines to show your healthcare provider and pharmacist when you get a new medicine.
are pregnant or plan to become pregnant. It is not known if COSENTYX can harm your unborn baby. You and your doctor should decide if you will use COSENTYX.
are breastfeeding or plan to breastfeed. It is not known if COSENTYX passes into your breast milk.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch ↗, or call 1-800-FDA-1088.

Please see full Prescribing Information, including Medication Guide.

10/23 308659

Results fast. Clear skin that can last.

See before and after pictures of how well COSENTYX works on troublesome areas, like the scalp, nails, palms, and bottoms of feet.

.

Scalp

Nails

Palms

Bottoms of feet

Real people are seeing and feeling real results, especially on troublesome areas:

Individual results may vary. LauraLee was compensated for her time.

Individual results may vary. Dewey was compensated for his time.