How Does COSENTYX Work? | COSENTYX® (secukinumab)

For people 6+ with moderate to severe plaque psoriasis

How does COSENTYX work for Plaque Psoriasis?

Watch the video to see how COSENTYX is thought to work to help people with plaque psoriasis (PsO).^†

Did you know an overactive immune system is like an overactive tennis ball machine? There are multiple molecules in the body that may play a role in causing inflammation. The IL-17A molecule is one of them.

Patient portrayal of how COSENTYX works.
^†The relationship between how COSENTYX works in the body and how it affects your symptoms is unknown.

Feel relief fast. Get clear skin that can last.

In clinical trials, the majority of adults taking COSENTYX 300 mg were clear or almost clear at 12 weeks. Approximately 8 out of 10 people saw 75% skin clearance. Approximately 6 out of 10 people saw 90% skin clearance. Many who saw results at 1 year maintained them at 5 years.^‡

Among adults who kept a symptom diary (39% of people), improvement in plaque psoriasis symptoms like pain, itching, and scaling was seen in those taking COSENTYX after just 12 weeks.^§

^‡After 3 years, patients and doctors were told which medication was being used. Knowing the study drug being used may affect the results.
^§Compared to those not taking COSENTYX.

REAL TALK: What makes this PsO treatment different?

SEE Brenelle talk to an expert to uncover more facts about how COSENTYX works.

Participants were compensated for their time.

COSENTYX is the first FDA-approved biologic treatment of its kind.

What is a biologic?

A biologic is a protein-based medication that is made from living sources and is taken by injection or infusion.

COSENTYX is designed to target and block IL-17A, which is believed to play a role in inflammation that causes psoriasis plaques and joint pain in people with psoriatic arthritis.

Why is IL-17A important?

With psoriasis, an overactive immune system overproduces certain molecules, one of which is IL-17A, which is believed to play a role in inflammation and causes painful, itchy plaques to appear on the skin.^¶ In some people, this inflammation can also cause pain in the joints. COSENTYX is the first and most prescribed^§ FDA-approved IL-17A blocker.

^¶Across all indications combined.

Cyndi 4.0 Photo — Individual results may vary. Cyndi was compensated for her time.

"I started summer 2015, so it's 5 years and counting for me. I'm just so grateful to be clear."

Real results. Real relief.

Real people with psoriasis are seeing and feeling real results with COSENTYX, even in bothersome areas. Learn more.

Tap to see IMPORTANT SAFETY INFORMATION AND APPROVED USES

IMPORTANT SAFETY INFORMATION

Do not use COSENTYX if you have had a severe allergic reaction to secukinumab or any of the other ingredients in COSENTYX. See the Medication Guide for a complete list of ingredients.

What is the most important information I should know about COSENTYX?

COSENTYX is a medicine that affects your immune system. COSENTYX may increase your risk of having serious side effects such as…

Do not use COSENTYX if you have had a severe allergic reaction to secukinumab or any of the other ingredients in COSENTYX. See the Medication Guide for a complete list of ingredients.

What is the most important information I should know about COSENTYX?

COSENTYX is a medicine that affects your immune system. COSENTYX may increase your risk of having serious side effects such as:

Infections

COSENTYX may lower the ability of your immune system to fight infections and may increase your risk of infections. Some people have died from these infections.

Your doctor should check you for tuberculosis (TB) before starting treatment with COSENTYX.
If your doctor feels that you are at risk for TB, you may be treated with medicine for TB before you begin treatment with COSENTYX and during treatment with COSENTYX.
Your doctor should watch you closely for signs and symptoms of TB during treatment with COSENTYX. Do not use COSENTYX if you have an active TB infection.

Before starting COSENTYX, tell your doctor if you:

are being treated for an infection
have an infection that does not go away or that keeps coming back
have TB or have been in close contact with someone with TB
think you have an infection or have symptoms of an infection such as: fevers, sweats, or chills; muscle aches; cough; shortness of breath; blood in your phlegm; weight loss; warm, red, or painful skin or sores on your body; diarrhea or stomach pain; burning when you urinate or urinate more often than normal

After starting COSENTYX, call your doctor right away if you have any signs of infection listed above. Do not use COSENTYX if you have any signs of infection unless you are instructed to by your doctor.

What are the possible side effects of COSENTYX?

COSENTYX may cause serious side effects, including:

Serious allergic reactions

Serious allergic reactions can occur. Get emergency medical help right away if you get any of the following symptoms: feeling faint; swelling of your face, eyelids, lips, mouth, tongue, or throat; trouble breathing or throat tightness; chest tightness; skin rash or hives (red, itchy bumps).

If you have a severe allergic reaction, do not give another injection of COSENTYX.

Inflammatory bowel disease

New cases of inflammatory bowel disease or "flare-ups" can happen with COSENTYX, and can sometimes be serious. If you have inflammatory bowel disease (ulcerative colitis or Crohn's disease), tell your doctor if you have worsening disease symptoms during treatment with COSENTYX or develop new symptoms of stomach pain or diarrhea.

Severe skin reactions that look like eczema can happen during treatment with COSENTYX from days to months after your first dose and can sometimes lead to hospitalization. Your doctor may temporarily stop treatment with COSENTYX if you develop severe skin reactions. Tell your doctor if you have any of the following signs or symptoms: redness or rash; itching; small bumps or patches; your skin is dry or feels like leather; blisters on the hands or feet that ooze or become crusty or skin peeling.

The most common side effects of COSENTYX include: cold symptoms, diarrhea, and upper respiratory tract infections.

These are not all of the possible side effects of COSENTYX. Call your doctor for medical advice about side effects.

Before using COSENTYX, tell your doctor if you:

have any of the conditions or symptoms listed above for infections.
have inflammatory bowel disease (Crohn's disease or ulcerative colitis).
are allergic to latex. The needle cap on the COSENTYX Sensoready® pen, and 150 mg/mL and 75 mg/0.5 mL prefilled syringes contains latex.
have recently received or are scheduled to receive an immunization (vaccine). People who take COSENTYX should not receive live vaccines. Children should be brought up to date with all vaccines before starting COSENTYX.
have any other medical conditions and all the medicines you take, including prescription and over‑the‑counter medicines, vitamins, and herbal supplements. Keep a list of your medicines to show your healthcare provider and pharmacist when you get a new medicine.
are pregnant or plan to become pregnant. It is not known if COSENTYX can harm your unborn baby. You and your doctor should decide if you will use COSENTYX.
are breastfeeding or plan to breastfeed. It is not known if COSENTYX passes into your breast milk.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch ↗, or call 1-800-FDA-1088 ↗.

Please see full Prescribing Information ↗, including Medication Guide ↗.

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Watch the video to see how COSENTYX is thought to work to help people with plaque psoriasis (PsO).^†

Feel relief fast. Get clear skin that can last.