ERA or JPsA Treatment | COSENTYX® (secukinumab)

For people with plaque psoriasis (6+) or ERA (4+) or PsA (2+)

COSENTYX helps kids and teens with Enthesitis-Related Arthritis (ERA) and Juvenile Psoriatic Arthritis (JPsA), 2 forms of juvenile idiopathic arthritis (JIA), the most common juvenile arthritis (JA).

In a clinical trial of kids and teens with enthesitis-related arthritis (ERA) or juvenile psoriatic arthritis (JPsA) taking COSENTYX^® (secukinumab):

Those with ERA had a 53% reduced risk of flares
Those with JPsA had an 85% reduced risk of flares

A flare is when your child's symptoms become worse without much improvement, and involves at least 2 joints.

For more on real relief with COSENTYX, download our brochure.

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SYMPTOM IMPROVEMENT IN AS EARLY AS 12 WEEKS.

In a clinical trial of kids and teens taking COSENTYX, 6 key areas were observed. Most (91% with JPsA and 85% with ERA) showed at least a 30% improvement in 3 or more of the 6 key areas, with worsening in no more than 1 key area, after 12 weeks of treatment.

The doctor's assessment of disease activity
The parent's or child's assessment of overall well-being
Difficulty doing daily activities
Number of joints affected by active arthritis
Number of joints that are hard to move
Lab test that measures inflammation

UNDERSTAND ERA & JPSA, THE TWO MOST COMMON FORMS OF JA

ERA

Enthesitis-related arthritis (ERA) is a type of JIA that affects the tissue where the muscles, ligaments, or tendons meet the bone (entheses). Symptoms may include swelling, joint pain, and stiffness at the hips, knees, and feet. The fingers, elbows, pelvis, chest, and lower back can also be affected.

JPsA

Juvenile psoriatic arthritis (JPsA) is a type of JIA that may include symptoms of both arthritis and plaque psoriasis. Arthritis symptoms can show up before skin symptoms and may affect 1 or more joints, often in the wrists, ankles, fingers, or toes. Psoriasis can appear as a scaly rash behind the ears, on the eyelids, elbows, knees, belly button, or scalp.

COSENTYX has proven experience

When you’re considering COSENTYX as a treatment for your child’s ERA or JPsA, you should know that COSENTYX is the most prescribed medicine of its kind,^† and is approved to treat pediatric plaque psoriasis.

Over 3.7 million prescriptions of COSENTYX have been filled^† in the United States*
Well-studied safety profile since its launch in 2015
No blood tests or routine lab monitoring required during treatment with COSENTYX
COSENTYX has been studied extensively for more than 16 years in dozens of clinical trials across all indications. More clinical trials are ongoing as we stay committed to studying COSENTYX.

*Across all indications combined.
^†As of March 2023.

Convenient once-a-month dosing,^‡ guided by your child’s weight

Your child’s doctor will prescribe the dose of COSENTYX that’s right for your child based on their weight. Your child will take COSENTYX once a week for 5 weeks, then just once a month afterward. This can mean fewer interruptions in both your and your child’s daily routines.

Dosing chart showing dosing schedule. To start once weekly for 5 weeks. Continue once monthly.

If your child weighs 33 lbs or more but less than 110 lbs, the recommended dose of COSENTYX is 75 mg. If your child weighs 110 lbs or more, the recommended dose is 150 mg.
COSENTYX requires just 1 injection for each dose (a prefilled syringe for a 75-mg dose or a prefilled syringe or Sensoready^® Pen for a 150-mg dose).

^‡Monthly dose equals 1 dose every 4 weeks.

How does COSENTYX work?

Having ERA or JPsA means your child has an overactive immune system. COSENTYX is a biologic treatment that works within the body's immune system to selectively target and block just the IL-17A molecule, which may play a role in causing inflammation throughout the body when it is overproduced. Blocking IL-17A may help reduce the inflammation causing the joint pain and stiffness your child feels.

What is a biologic?

A biologic is a protein-based medication that is made from living sources and is taken by injection or infusion.

COSENTYX^® Connect is here for you throughout your child's treatment.

COSENTYX^® Connect is a free support program for people taking or considering COSENTYX. Our goal is to make the COSENTYX experience as easy, affordable, and convenient as possible for you and your child. Sign up now and you'll have access to a full range of services and support, like a COSENTYX^® Connect Team Member, co-pay,* if privately insured and otherwise eligible, and injection resources.

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Tap to see IMPORTANT SAFETY INFORMATION AND APPROVED USES

IMPORTANT SAFETY INFORMATION

Do not use COSENTYX if you have had a severe allergic reaction to secukinumab or any of the other ingredients in COSENTYX. See the Medication Guide for a complete list of ingredients.

What is the most important information I should know about COSENTYX?

COSENTYX is a medicine that affects your immune system. COSENTYX may increase your risk of having serious side effects such as…

Do not use COSENTYX if you have had a severe allergic reaction to secukinumab or any of the other ingredients in COSENTYX. See the Medication Guide for a complete list of ingredients.

What is the most important information I should know about COSENTYX?

COSENTYX is a medicine that affects your immune system. COSENTYX may increase your risk of having serious side effects such as:

Infections

COSENTYX may lower the ability of your immune system to fight infections and may increase your risk of infections. Some people have died from these infections.

Your doctor should check you for tuberculosis (TB) before starting treatment with COSENTYX.
If your doctor feels that you are at risk for TB, you may be treated with medicine for TB before you begin treatment with COSENTYX and during treatment with COSENTYX.
Your doctor should watch you closely for signs and symptoms of TB during treatment with COSENTYX. Do not use COSENTYX if you have an active TB infection.

Before starting COSENTYX, tell your doctor if you:

are being treated for an infection
have an infection that does not go away or that keeps coming back
have TB or have been in close contact with someone with TB
think you have an infection or have symptoms of an infection such as: fevers, sweats, or chills; muscle aches; cough; shortness of breath; blood in your phlegm; weight loss; warm, red, or painful skin or sores on your body; diarrhea or stomach pain; burning when you urinate or urinate more often than normal

After starting COSENTYX, call your doctor right away if you have any signs of infection listed above. Do not use COSENTYX if you have any signs of infection unless you are instructed to by your doctor.

What are the possible side effects of COSENTYX?

COSENTYX may cause serious side effects, including:

Serious allergic reactions

Serious allergic reactions can occur. Get emergency medical help right away if you get any of the following symptoms: feeling faint; swelling of your face, eyelids, lips, mouth, tongue, or throat; trouble breathing or throat tightness; chest tightness; skin rash or hives (red, itchy bumps).

If you have a severe allergic reaction, do not give another injection of COSENTYX.

Inflammatory bowel disease

New cases of inflammatory bowel disease or "flare-ups" can happen with COSENTYX, and can sometimes be serious. If you have inflammatory bowel disease (ulcerative colitis or Crohn's disease), tell your doctor if you have worsening disease symptoms during treatment with COSENTYX or develop new symptoms of stomach pain or diarrhea.

Severe skin reactions that look like eczema can happen during treatment with COSENTYX from days to months after your first dose and can sometimes lead to hospitalization. Your doctor may temporarily stop treatment with COSENTYX if you develop severe skin reactions. Tell your doctor if you have any of the following signs or symptoms: redness or rash; itching; small bumps or patches; your skin is dry or feels like leather; blisters on the hands or feet that ooze or become crusty or skin peeling.

The most common side effects of COSENTYX include: cold symptoms, diarrhea, and upper respiratory tract infections.

These are not all of the possible side effects of COSENTYX. Call your doctor for medical advice about side effects.

Before using COSENTYX, tell your doctor if you:

have any of the conditions or symptoms listed above for infections.
have inflammatory bowel disease (Crohn's disease or ulcerative colitis).
are allergic to latex. The needle cap on the COSENTYX Sensoready® pen, and 150 mg/mL and 75 mg/0.5 mL prefilled syringes contains latex.
have recently received or are scheduled to receive an immunization (vaccine). People who take COSENTYX should not receive live vaccines. Children should be brought up to date with all vaccines before starting COSENTYX.
have any other medical conditions and all the medicines you take, including prescription and over‑the‑counter medicines, vitamins, and herbal supplements. Keep a list of your medicines to show your healthcare provider and pharmacist when you get a new medicine.
are pregnant or plan to become pregnant. It is not known if COSENTYX can harm your unborn baby. You and your doctor should decide if you will use COSENTYX.
are breastfeeding or plan to breastfeed. It is not known if COSENTYX passes into your breast milk.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch ↗, or call 1-800-FDA-1088.

Please see full Prescribing Information, including Medication Guide.

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